Top 10 Glutathione Supplements Reviewed

Direct forms of Glutathione include: L-Glutathione, Liposomal Glutathione and Acetyl Glutathione.

Glutathione Precursors are ingredients that promote the body’s natural ability to produce Glutathione. A few examples of Glutathione precursors include: N Acetyl-L-Cysteine, Alpha Lipoic Acid, Milk Thistle Extract and Selenium.

Top 10 Glutathione Supplements

In no particular order.



  • No Direct Form of Glutathione
  • Has Precursors to Improve GSH Synthesis

Ingredients: Vitamin C 250 mg
L-Glutamine 750 mg
N-Acetyl Cysteine 375 mg
Alpha Lipoic Acid 75 mg

Proprietary Blend: 488 mg
(Cordyceps, N-Acetyl D-Glucosamine, Quercetin, Milk Thistle Extract)

MAX GXL Website

GSH Gold

  • Has Direct Form of Glutathione
  • Has Precursors to Improve GSH Synthesis

Ingredients: Vitamin C 200 mg
Vitamin D 1000 IU
Vitamin E 50 IU
Vitamin B2 1 mg
Vitamin B6 20 mg
Folate 400 mcg
Vitamin B12 400 mcg
Selenium 50 mcg
N-Acetyl-L-Cysteine 500 mg
L-Glutathione 200 mg
Acetyl L-Carnitine 100 mg
Alpha Lipoic Acid 50 mg
Milk Thistle Seed Extract 50 mg
CoQ10 (Ubiquinol) 15 mg

GSH GOLD Website

Jarrow Formulas

  • Has Direct Form of Glutathione
  • No Precursors to Improve GSH Synthesis

Ingredients: Glutathione (Reduced) 500 mg


Rob Keller

Original Glutathione Formula

  • No Direct Form of Glutathione
  • Has Precursors to Improve GSH Synthesis

Ingredients: Vitamin C 250 mg
N-Acetyl Cysteine 375 mg
Alpha Lipoic Acid 75 mg

Proprietary Blend: 488 mg
(Cordyceps, N-Acetyl D-Glucosamine, Quercetin, Milk Thistle Extract)



Upgraded Glutathione Force

  • Has Direct Form of Glutathione
  • No Precursors to Improve GSH Synthesis

Ingredients: Reduced Glutathione 100 mg


Puritan’s Pride

  • Has Direct Form of Glutathione
  • No Precursors to Improve GSH Synthesis

Ingredients: L-Glutathione Free Form 500 mg



  • No Direct Form of Glutathione
  • Has Precursors to Improve GSH Synthesis

Ingredients: Vitamin C 42.5 mg
Selenium 12.5 mg
Riboceine (D-Ribose-L-Cysteine 125 mg

Proprietary Blend: 580 mg
(Cordyceps, Curcumin, Resveratrol, Alpha Lipoic Acid, Grape Seed Extract, Quercetin, Milk Thistle Extract, Broccoli Extract, Aloe Extract, BioPerine)


New Roots

  • Has Direct Form of Glutathione
  • No Precursors to Improve GSH Synthesis

Ingredients: Glutathione 200 mg
Vitamin C 50 mg


LivOn Labs

Lypo-Spheric GSH

  • Has Direct Form of Glutathione
  • No Precursors to Improve GSH Synthesis

Ingredients: Setria® Glutathione (reduced) 450 mg
Essential Phospholipids (from soy lecithin) 1,000 mg
Phosphatidylcholine 500 mg



  • Has Direct Form of Glutathione
  • No Precursors to Improve GSH Synthesis

Ingredients: Setria® L-Glutathione 500 mg

GNC Website

Dr Mark Hyman’s Glutathione Video

Dr. Mark Hyman did a video on Glutathione back in 2007, it is still one of the very best informational sources on “the mother of antioxidants”. While some of the science has been updated since the video was released, the vast majority of it is spot on. If you haven’t already seen it, here is the 9 minute video that could dramatically change your life.

Dr Mark Hyman on Glutathione

Dr. Hyman has done wonders for raising awareness for our body’s most important antioxidant, contributing to many high profile publications. Despite his tireless efforts, too few people know about Glutathione and how vital it is to our health.

Glutathione is considered the fountain of youth of the supplement world. With profound anti-aging benefits, ability to improve energy levels and our body’s natural defense against infection and disease.

Dr. Hyman’s article in the Huffington Post is also worth a read. Again, the science is a bit outdated, but the overall message is as important as ever.

How To Supplement Glutathione

The latest research shows that by supplementing with L-glutathione, you can improve GSH levels effectively.

Precursors that provide the body with the building blocks to synthesize its own GSH naturally are among the most effective ways to supplement GSH levels. These include N Acetyl-L-Cysteine, Alpha Lipoic Acid, B Vitamins, Selenium and Milk Thistle.

Supporting Glutathione levels on a daily basis is one of the single most effective ways to naturally optimize your health.

N Acetyl-L-Cysteine Benefits

It is impossible to discuss the benefits of Glutathione without mentioning N Acetyl-L-Cysteine. Glutathione is made up of three amino acids, glycine, L-glutamic acid and L-cysteine. L-cysteine is the “rate limiting factor” in Glutathione production. Meaning we have ample amounts of glycine and L-glutamic acid, but we depend on dietary sources & supplements containing L-cysteine in order to naturally produce Glutathione. N Acetyl-L-Cysteine benefits our health beyond boosting our Glutathione levels, yielding powerful health benefits all its own.

NAC Benefits

N Acetyl-L-Cysteine benefits are almost as vast in number as Glutathione. While these two super-star antioxidants are closely tied together, they also offer a plethora of benefits unique to themselves. Here are just a handful of the benefits NAC has to offer.

Boosts Glutathione Production

As mentioned above, NAC helps boost the body’s natural Glutathione production. Providing our cells with the ability to synthesize ample amounts of this master-detoxifier. Supplementing with N Acetyl-L-Cysteine is one of the best ways to naturally boost Glutathione levels and promote total body health. [1]

Reduces Oxidative Stress

Damaging our cells, speeding up the aging process and contributing to a plethora of health conditions, oxidative stress is detrimental to our health and life. It is a natural byproduct of the metabolic cycle, but when levels are left unchecked, it can be extremely harmful. NAC is able to reduce oxidative stress levels throughout the body, improving cellular health and staving off disease. [1]

Reduces Muscle Fatigue

NAC can help reduce muscle fatigue during prolonged exercise. It can also help reduce pulmonary muscle fatigue, potentially boosting lung function and stamina. During prolonged exercise, our muscles use up Glutathione in order to fight the excessive production of Free Radical Species. Supplementing NAC helps promote GSH production, replenishing the muscles GSH concentrations. [2]

Reduces Homocysteine Levels

Elevated levels of Homocysteine have been correlated with the occurrence of blood clots, strokes and heart attacks. Homocysteine can be recycled into methionine or cysteine by certain B-vitamins. NAC has been shown to improve plasma homocysteine levels as well as pulse pressure. [3]

Helps Treat Infertility

Male fertility is affected by a variety of factors, including oxidative stress levels and antioxidant activity. NAC has been found to significantly improve the status of sperm volume, motility and viscosity of semen. While NAC isn’t an outright cure for male infertility, it can be a hugely beneficial adjunct therapy. [4]

Inhibits the Influenza Virus

N Acetyl-L-Cysteine has been shown to inhibit replication and proliferation of the influenza virus. The powerful effect NAC has on the influenza virus can help minimize symptoms, reduce the lifespan of the virus and even prevent symptoms from popping up altogether. This makes NAC a must have supplement during flu season. [5]

Reduces Heavy Metal Toxicity

Toxic heavy metals such as lead, cadmium and mercury pose a severe health risk. Generating excess free radicals and impairing our body’s natural antioxidant defenses. NAC has been found to counter these harmful effects, reducing the accumulation of these heavy metals in certain tissues. Left unchecked, these heavy metals accumulate in the body and cause severe tissue damage, inflammation and increase the risk of neurodegenerative disorders. [6]

Promotes Liver Health

NAC has long been used as a clinical therapy for acetaminophen acute liver failure, detoxifying the liver and restoring function. N Acetyl-L-Cysteine has also been found to improve the condition of those suffering from non-acetaminophen liver failure. Restoring GSH levels which help detoxify the liver, repair damaged cells and restore optimal function. [7, 8]


As a natural anti-inflammatory, NAC helps protect against Blood-Brain-Barrier dysfunction caused by systemic inflammation. This has been found to help reduce the risk of developing Alzheimer’s Disease. These same anti-inflammatory benefits are present across the body. Limiting inflammatory markers and reducing oxidative stress in the process. [9]

Boosts Immune Function

Our immune function is largely dependant on the level of antioxidants in our body. NAC boosts GSH levels, and it is also a powerful antioxidant all its own. This promotes our body’s natural immune function, fighting infection, disease and illness through natural mechanisms. [1]

Bipolar Disorder

Often touted for its cognitive benefits, it comes as little surprise that NAC can also improve many psychiatric conditions. Individuals with Bipolar Disorder who supplemented NAC daily were found to have significant improvements in mood, global functioning and social / occupational functioning. [10]

Autism Spectrum Disorder

The anti-inflammatory and antioxidant benefits of NAC are paramount for those with Autism, as they are far more vulnerable to toxins, oxidative stress and inflammation. N Acetyl-L-Cysteine has also been found to improve irritability in children on the Autism Spectrum. Proving it is a promising potential treatment option for those with ASD. [11, 12]

Helps Treat Addiction

The neurological benefits of NAC have been shown to improve the condition of those suffering from addiction. Reducing cravings and withdrawal symptoms in those with a cocaine addiction, reducing cravings in adolescents with a marijuana dependence, significantly reducing gambling behavior in pathological gamblers and even helping people kick their nicotine habit. These same mechanisms may also be responsible for NAC’s ability to improve compulsive behaviors in individuals with Obsessive Compulsive Disorder (OCD). [13, 14]

Using Glutathione to Whiten Skin Tone

Glutathione is extremely popular for its skin whitening benefits, lightening skin tone and improving skin condition. The skin whitening benefits of Glutathione are a result of its ability to significantly lower the melanin index.

Melanin is the substance produced by the body in order to give our skin, hair and eyes their color. The more melanin produced, the darker the pigment.

How Does Glutathione Whiten Skin So Effectively?

The effects of Glutathione for lightening the skin can vary widely. Studies have shown that the best results are achieved when it is used topically in a cream form. By using oxidized Glutathione (GSSG) topically, you can help suppress wrinkles, improve skin smoothness, increase moisture content and the skins elasticity. All with no adverse side effects according to the latest study. [1]

Oral Glutathione supplements have also been found to lighten skin color, however the results were not quite as promising as those of the skin creams. [2] The major benefit of supplementing Glutathione orally is due to its ability to dramatically improve antioxidant activity in the body. Effectively detoxing the body which in turn, improves skin condition.

Melanin is the substance that gives our skin its color, as mentioned before. It is produced by the oxidation of the amino acid tyrosine. The pigment is produced by a specialized group of cells called melanocytes. Glutathione helps prevent the activation of tyrosine through its ability to reduce free radical formation in the body. These free radicals can activate the tyrosine which ramps up melanin production.

So Much More Than Just Skin Whitening

It may have been popularized because of its ability to lighten skin tone, a benefit that many people are interested in. But Glutathione is so much more, it is our body’s master antioxidant, responsible for the health and well-being of every cell.

Our body contains trillions of cells, virtually every single one depends on Glutathione in order to survive and function properly. By Supporting this remarkable antioxidant with a quality oral supplement, you can help improve skin quality, liver function, brain health, cardiovascular health and so much more.
Glutathione has been the subject of interest for over 80,000 scientific studies. It has been found to improve the condition of patients with a vast array of different medical ailments.

Unfortunately very few people have heard of Glutathione, the majority only know of it because of its skin whitening effects. What’s worse, is almost everyone over the age of 20 years old is deficient in GSH. This is because there are so many factors in our modern environment that deplete our bodies of this master antioxidant. This speeds up the aging process and leaves us vulnerable to infection and disease.

Support your Glutathione levels with a high quality supplement, healthy diet and daily activity.