N Acetyl-L-Cysteine Benefits

It is impossible to discuss the benefits of Glutathione without mentioning N Acetyl-L-Cysteine. Glutathione is made up of three amino acids, glycine, L-glutamic acid and L-cysteine. L-cysteine is the “rate limiting factor” in Glutathione production. Meaning we have ample amounts of glycine and L-glutamic acid, but we depend on dietary sources & supplements containing L-cysteine in order to naturally produce Glutathione. N Acetyl-L-Cysteine benefits our health beyond boosting our Glutathione levels, yielding powerful health benefits all its own.

NAC Benefits

N Acetyl-L-Cysteine benefits are almost as vast in number as Glutathione. While these two super-star antioxidants are closely tied together, they also offer a plethora of benefits unique to themselves. Here are just a handful of the benefits NAC has to offer.

Boosts Glutathione Production

As mentioned above, NAC helps boost the body’s natural Glutathione production. Providing our cells with the ability to synthesize ample amounts of this master-detoxifier. Supplementing with N Acetyl-L-Cysteine is one of the best ways to naturally boost Glutathione levels and promote total body health. [1]

Reduces Oxidative Stress

Damaging our cells, speeding up the aging process and contributing to a plethora of health conditions, oxidative stress is detrimental to our health and life. It is a natural byproduct of the metabolic cycle, but when levels are left unchecked, it can be extremely harmful. NAC is able to reduce oxidative stress levels throughout the body, improving cellular health and staving off disease. [1]

Reduces Muscle Fatigue

NAC can help reduce muscle fatigue during prolonged exercise. It can also help reduce pulmonary muscle fatigue, potentially boosting lung function and stamina. During prolonged exercise, our muscles use up Glutathione in order to fight the excessive production of Free Radical Species. Supplementing NAC helps promote GSH production, replenishing the muscles GSH concentrations. [2]

Reduces Homocysteine Levels

Elevated levels of Homocysteine have been correlated with the occurrence of blood clots, strokes and heart attacks. Homocysteine can be recycled into methionine or cysteine by certain B-vitamins. NAC has been shown to improve plasma homocysteine levels as well as pulse pressure. [3]

Helps Treat Infertility

Male fertility is affected by a variety of factors, including oxidative stress levels and antioxidant activity. NAC has been found to significantly improve the status of sperm volume, motility and viscosity of semen. While NAC isn’t an outright cure for male infertility, it can be a hugely beneficial adjunct therapy. [4]

Inhibits the Influenza Virus

N Acetyl-L-Cysteine has been shown to inhibit replication and proliferation of the influenza virus. The powerful effect NAC has on the influenza virus can help minimize symptoms, reduce the lifespan of the virus and even prevent symptoms from popping up altogether. This makes NAC a must have supplement during flu season. [5]

Reduces Heavy Metal Toxicity

Toxic heavy metals such as lead, cadmium and mercury pose a severe health risk. Generating excess free radicals and impairing our body’s natural antioxidant defenses. NAC has been found to counter these harmful effects, reducing the accumulation of these heavy metals in certain tissues. Left unchecked, these heavy metals accumulate in the body and cause severe tissue damage, inflammation and increase the risk of neurodegenerative disorders. [6]

Promotes Liver Health

NAC has long been used as a clinical therapy for acetaminophen acute liver failure, detoxifying the liver and restoring function. N Acetyl-L-Cysteine has also been found to improve the condition of those suffering from non-acetaminophen liver failure. Restoring GSH levels which help detoxify the liver, repair damaged cells and restore optimal function. [7, 8]


As a natural anti-inflammatory, NAC helps protect against Blood-Brain-Barrier dysfunction caused by systemic inflammation. This has been found to help reduce the risk of developing Alzheimer’s Disease. These same anti-inflammatory benefits are present across the body. Limiting inflammatory markers and reducing oxidative stress in the process. [9]

Boosts Immune Function

Our immune function is largely dependant on the level of antioxidants in our body. NAC boosts GSH levels, and it is also a powerful antioxidant all its own. This promotes our body’s natural immune function, fighting infection, disease and illness through natural mechanisms. [1]

Bipolar Disorder

Often touted for its cognitive benefits, it comes as little surprise that NAC can also improve many psychiatric conditions. Individuals with Bipolar Disorder who supplemented NAC daily were found to have significant improvements in mood, global functioning and social / occupational functioning. [10]

Autism Spectrum Disorder

The anti-inflammatory and antioxidant benefits of NAC are paramount for those with Autism, as they are far more vulnerable to toxins, oxidative stress and inflammation. N Acetyl-L-Cysteine has also been found to improve irritability in children on the Autism Spectrum. Proving it is a promising potential treatment option for those with ASD. [11, 12]

Helps Treat Addiction

The neurological benefits of NAC have been shown to improve the condition of those suffering from addiction. Reducing cravings and withdrawal symptoms in those with a cocaine addiction, reducing cravings in adolescents with a marijuana dependence, significantly reducing gambling behavior in pathological gamblers and even helping people kick their nicotine habit. These same mechanisms may also be responsible for NAC’s ability to improve compulsive behaviors in individuals with Obsessive Compulsive Disorder (OCD). [13, 14]

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